PlatformADCC ASSAYS – ROUTINE HASSLE
Brink Biologics, Inc. holds the exclusive non-clinical rights to the NK-92®️ cell line and its CD16 expressing derivatives, all of which are uniquely and ideally suited for antibody-dependent cell-mediated cytotoxicity (ADCC) assays.
OUR SIMPLE SOLUTION
The exclusive global provider of NK-92® cell line testing services, products, and sublicenses within the life sciences and device industry.
Relevant Examples:
Schnueriger, A., et al. (2011). “Development of a quantitative, cell-line based assay to measure ADCC activity mediated by therapeutic antibodies.” Mol Immunol 48(12-13): 1512-1517.
Brink Biologics created the NK-92® master cell bank (MCB).
NEUKOPANEL® CELL LINES
Brink Biologics, Inc. Neukopanel® cell lines are developed from proprietary NK-92® cells and are made available for non-clinical applications by the only authorized distributor of NK-92® cells.
Five Advantages of the Neukopanel® Cell Lines:
For the first time the means to establish a consistent, robust and reliable assay for assessment of true ADCC function.
Cost and Time Savings
True Cytotoxicity
Ease of Use
Robust Assay
Eliminates Phenotypic Variability
- Cost and time savings over common practice using donor-sourced (PBMC) NK cell isolation, expansion and maintenance in short term cultures
- Eliminates phenotypic variability of donor-sourced NK cells as Neukopanel cell lines offer clonal consistency, purity and reliability as an assay reagent
- Ease of use over donor-sourced NK cells and capable of long-term continuous cultures
- Ability to generate a readout spectrum with the use of our homozygous high and low affinity CD16 expressing lines alongside our negative control line for assay robustness
- True cytotoxicity rather than cell-binding readouts
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