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NK-92-Authenticity-Stamp-HRv21-11-Nov-2018-LRNeukopanel® Cell Line Platform

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A NEUKOPANEL® OF NEUKOPLAST® NK-92 CELL LINES SUITABLE FOR A RANGE OF LABORATORY TESTING APPLICATIONS

ADCC ASSAYS – ROUTINE HASSLE

Brink Biologics, Inc. holds the exclusive non-clinical rights to the NK-92®️ cell line and its CD16 expressing derivatives, all of which are uniquely and ideally suited for antibody-dependent cell-mediated cytotoxicity (ADCC) assays.

ROUTINE ASSAY
TIME CONSUMING AND A LACK OF OPTIONS

OUR SIMPLE SOLUTION

The exclusive global provider of NK-92® cell line testing services, products, and sublicenses within the life sciences and device industry.

Highly published cell lines – over 200 publications.
Relevant Examples:
Schnueriger, A., et al. (2011). “Development of a quantitative, cell-line based assay to measure ADCC activity mediated by therapeutic antibodies.” Mol Immunol 48(12-13): 1512-1517.

Binyamin, L., et al. (2008). “Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy.” J Immunol 180(9): 6392-6401.

NK-92® cells are the only continuously growing human NK cell adapted to mass production
Brink Biologics created the NK-92® master cell bank (MCB).
EXCLUSIVE

NK-92® MCB has been accepted as clinical grade material by regulatory agencies across the world, including the US FDA, EMEA and Canada Health.
RECOGNIZED QUALITY

The sole holder of homogeneously pure NK-92® cell cultures with superb retention of phenotypic characteristics in more than 6 months of continuous culture.
PURE CELL LINE

NEUKOPANEL® CELL LINES

Brink Biologics, Inc. Neukopanel® cell lines are developed from proprietary NK-92® cells and are made available for non-clinical applications by the only authorized distributor of NK-92® cells.

Five Advantages of the Neukopanel® Cell Lines:

For the first time the means to establish a consistent, robust and reliable assay for assessment of true ADCC function.

Cost and Time Savings

 

True Cytotoxicity

 

Ease of Use

 

Robust Assay

 

Eliminates Phenotypic Variability

 
  • Cost and time savings over common practice using donor-sourced (PBMC) NK cell isolation, expansion and maintenance in short term cultures
  • Eliminates phenotypic variability of donor-sourced NK cells as Neukopanel cell lines offer clonal consistency, purity and reliability as an assay reagent
  • Ease of use over donor-sourced NK cells and capable of long-term continuous cultures
  • Ability to generate a readout spectrum with the use of our homozygous high and low affinity CD16 expressing lines alongside our negative control line for assay robustness
  • True cytotoxicity rather than cell-binding readouts

Office

3530 John Hopkins Court
San Diego, CA 92121

Hours

8am to 5pm M-F

Call Us

Main: (858) 633-0300
Fax: (858) 380-1999

Email: info@brinkbiologics.com

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‘Brink Biologics’, ‘Taking You Beyond the Brink of Binding’, ‘Neukopanel’, ‘Killer Assays’ and ‘laNK’ are trademarks or registered trademarks of Brink Biologics, Inc., ‘haNK’, 'Neukoplast', and ‘NK-92’ are registered trademarks of Nantkwest, Inc.
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